The final proposed system of RBC vasodilation while in the existence of nitrite may be the reduction of nitrite to NO by Hb. Brooks initially studied the nitrite Hb interaction in 1937 and this do the job was later extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to sort metHb and NO (Brooks, 1937; D